From the Boston area (about 2.5 hours)

Take I-93 north to I-89 north at Concord, N.H.
Get off I-89 at Exit 18 in Lebanon, NH onto Route 120.
Bear right off the exit, heading north on Rt.120 into Hanover.
4.1 miles from the exit, Rt. 120 forks at a traffic light.
Bear right at the fork, following Rt. 120 one-half mile on South Park Street to the second traffic light.
Turn left at the light, onto East Wheelock Street.
Follow East Wheelock for two-tenths of a mile. You will come to the Hopkins Center (left) and the Dartmouth Green (right).

From Burlington, Vt. (about 1.5 hours)

Take I-89 south to I-91 north in White River Junction, Vt. Follow I-91 N to exit 13, Norwich, Vt.  
Bear right off the exit, across the Ledyard Bridge spanning the Connecticut River.
Continue up the hill (West Wheelock Street) to the top of the hill and to the traffic light in the center of town, nine-tenths of a mile from the interstate exit.
On your left at the light is the Dartmouth Green; to your right is the Hanover Inn.

From New York (about 5 hours), southern New England and points south

Take I-91 north to exit 13 at Norwich, Vt.
Bear right off the exit, across the Ledyard Bridge spanning the Connecticut River.
Continue up the hill (West Wheelock Street) to the top of the hill and to the traffic light in the center of town, nine-tenths of a mile from the interstate exit.
On your left at the light is the Dartmouth Green; to your right is the Hanover Inn.